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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | ERA | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Juan Pineda | 2.570 | 2015-2029 | |
| 2 | Claudio Salinas | 2.768 | 2021-2033 | |
| 3 | Rafael Rodríguez | 2.781 | 2021-2038 | |
| 4 | Marcos Suárez# | 2.858 | 2023-2041 | |
| 5 | José Castaneda | 2.870 | 2021-2034 | |
| 6 | Diego Vela# | 2.885 | 2028-2043 | |
| 7 | Mario Robles | 2.907 | 2014-2027 | |
| 8 | Pedro Salas | 2.952 | 2015-2019 | |
| 9 | Felipe Canó | 3.034 | 2014-2019 | |
| 10 | Víctor Martínez | 3.043 | 2014-2029 | |
| 10 | Ángel Torres | 3.043 | 2014-2026 | |
| 12 | Juan Hernández | 3.077 | 2014-2019 | |
| 13 | Sandro Romero | 3.088 | 2014-2029 | |
| 14 | José Zúñiga# | 3.093 | 2018-2039 | |
| 15 | Alonso Aguilar | 3.103 | 2014-2025 | |
| 16 | Valentín Fernández# | 3.140 | 2028-2042 | |
| 17 | Guillermo Negrón# | 3.157 | 2026-2034 | |
| 18 | Javier Banda | 3.162 | 2021-2026 | |
| 19 | Pedro Cordero# | 3.172 | 2029-2043 | |
| 20 | Pancho Zumaya | 3.196 | 2014-2022 | |
| 21 | Jorge Castillo# | 3.209 | 2031-2034 | |
| 22 | José Aguilar | 3.218 | 2014-2026 | |
| 23 | Pepe Hernández | 3.222 | 2017-2037 | |
| 24 | José Pérez# | 3.238 | 2030-2043 | |
| 25 | Mario González | 3.292 | 2023-2042 | |
| 26 | José Rojas | 3.332 | 2022-2035 | |
| 27 | Sergio Maldonado | 3.344 | 2022-2035 | |
| 28 | Raúl Bernal | 3.358 | 2015-2028 | |
| 29 | José Cortéz | 3.365 | 2018-2039 | |
| 30 | Jesús Aquino | 3.381 | 2022-2033 | |
| 31 | Juan Avales | 3.396 | 2024-2034 | |
| 32 | Manuel Padilla | 3.416 | 2014-2017 | |
| 33 | Augusto Juárez | 3.430 | 2014-2021 | |
| 34 | José Luján | 3.462 | 2014-2022 | |
| 35 | Carlos García | 3.472 | 2014-2028 | |
| 36 | Raúl Márquez | 3.504 | 2017-2029 | |
| 37 | Carlos Urbina | 3.513 | 2016-2028 | |
| 38 | Jorge Martínez | 3.554 | 2014-2021 | |
| 39 | Luis Castillo | 3.560 | 2021-2027 | |
| 39 | Orlando García# | 3.560 | 2028-2041 | |
| 41 | Orlando Hernández | 3.567 | 2014-2026 | |
| 42 | Iván Mora# | 3.574 | 2033-2043 | |
| 43 | Augusto Gonzáles | 3.582 | 2019-2033 | |
| 44 | Júlio Vela | 3.615 | 2014-2024 | |
| 45 | Alberto Vázquez | 3.622 | 2014-2027 | |
| 46 | Ángel Solís | 3.624 | 2014-2026 | |
| 46 | Alejandro Miranda | 3.624 | 2015-2034 | |
| 48 | Emílio Soto# | 3.629 | 2029-2043 | |
| 49 | Javier Díaz | 3.639 | 2018-2034 | |
| 50 | Armando Mora# | 3.656 | 2038-2043 | |
| 51 | Felipe Ferreira | 3.662 | 2014-2024 | |
| 52 | Félix Estrada# | 3.674 | 2028-2043 | |
| 52 | Edgardo Rivera | 3.674 | 2014-2031 | |
| 54 | Cris Estronza | 3.682 | 2022-2030 | |
| 55 | Enrique Olivo | 3.685 | 2014-2030 | |
| 56 | Angelino Rodríguez# | 3.688 | 2031-2043 | |
| 57 | António Sosa | 3.726 | 2017-2031 | |
| 58 | António Ortíz# | 3.731 | 2039-2043 | |
| 59 | Albert Corona# | 3.732 | 2029-2034 | |
| 60 | Jorge Chávez | 3.773 | 2014-2022 | |
| 61 | Armando Cuestas | 3.775 | 2018-2031 | |
| 62 | Gilberto Sánchez# | 3.789 | 2033-2043 | |
| 63 | Raúl Díaz# | 3.790 | 2026-2040 | |
| 64 | Roberto Palácios | 3.820 | 2014-2021 | |
| 65 | Marcos Fernández# | 3.825 | 2034-2043 | |
| 66 | Omar Zumaya | 3.852 | 2017-2033 | |
| 67 | Jesús Alarcon | 3.855 | 2022-2037 | |
| 68 | Ramiro López# | 3.868 | 2029-2043 | |
| 69 | Mauro Mendoza | 3.874 | 2021-2027 | |
| 70 | Edgar Martínez# | 3.888 | 2026-2042 | |
| 71 | Jesús Pérez# | 3.912 | 2028-2033 | |
| 72 | Jorge Cervantes | 3.920 | 2019-2032 | |
| 73 | Ángel Sevares# | 3.929 | 2034-2040 | |
| 74 | Miguel Angel González | 3.932 | 2014-2022 | |
| 75 | Iván Toledo# | 3.937 | 2034-2043 | |
| 76 | José Olivas# | 3.965 | 2037-2043 | |
| 77 | Alfredo Pérez | 3.967 | 2025-2037 | |
| 78 | Juan Castro | 3.987 | 2021-2030 | |
| 79 | Juan Quiñonez | 3.995 | 2029-2036 | |
| 80 | Mario Bermúdez# | 4.027 | 2033-2043 | |
| 81 | Sergio Domínguez | 4.030 | 2025-2037 | |
| 82 | Ignacio Silva# | 4.047 | 2027-2043 | |
| 83 | Jaime Meza | 4.052 | 2014-2022 | |
| 84 | José Córdova | 4.053 | 2018-2030 | |
| 85 | Álex Fuentes# | 4.057 | 2033-2036 | |
| 86 | Vincente Colón# | 4.063 | 2022-2042 | |
| 87 | António Santana# | 4.069 | 2035-2043 | |
| 88 | António Vázquez | 4.072 | 2025-2036 | |
| 89 | Luis Torres | 4.073 | 2014-2025 | |
| 90 | Bernardo Navarro# | 4.107 | 2038-2043 | |
| 91 | Mauro Rodríguez# | 4.125 | 2034-2043 | |
| 92 | Luis Meléndez | 4.138 | 2014-2031 | |
| 93 | Pedro Ortíz | 4.147 | 2022-2036 | |
| 93 | Tony Garanzuay | 4.147 | 2025-2039 | |
| 95 | Félix Fuantes | 4.165 | 2016-2027 | |
| 96 | Pedro Tobías | 4.171 | 2014-2028 | |
| 97 | Júlio Rodríguez# | 4.182 | 2039-2043 | |
| 98 | León Flores# | 4.193 | 2030-2039 | |
| 99 | Ramiro Lozano | 4.208 | 2019-2035 | |
| 100 | Gerardo Ortíz | 4.210 | 2025-2035 |
