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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | ERA | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Juan López | 1.167 | 2040 | |
| 2 | Manuel Buytelaar | 1.256 | 2045 | |
| 3 | Samuel Avery | 1.441 | 2048 | |
| 4 | Héctor Vega | 1.461 | 2024 | |
| 5 | Guillermo Villarreal | 1.481 | 2023 | |
| 6 | Javier Defrese | 1.516 | 2006 | |
| 6 | Larry Duplessis* | 1.516 | 2011 | |
| 8 | Ryan Bodin | 1.526 | 2011 | |
| 9 | Denny Wolfe | 1.527 | 2037 | |
| 10 | Roku Takahashi | 1.531 | 2035 | |
| 11 | Dave Pineda# | 1.551 | 2069 | |
| 12 | Johnny Johnston | 1.559 | 2012 | |
| 13 | Victor Faucher | 1.575 | 2046 | |
| 14 | Wayne Fish | 1.626 | 1996 | |
| 15 | Fernando Varela | 1.627 | 2012 | |
| 16 | Dave Sutphin | 1.710 | 2022 | |
| 17 | Joseph Powers | 1.717 | 2035 | |
| 18 | Daniel Peters | 1.718 | 2019 | |
| 19 | Paul O'Neil | 1.734 | 2016 | |
| 20 | Justin Samsel# | 1.748 | 2069 | |
| 21 | Trent Croom | 1.796 | 2073 | |
| 22 | Buddy Jackson | 1.800 | 2011 | |
| 22 | José González | 1.800 | 2029 | |
| 22 | Alex Henderson | 1.800 | 2022 | |
| 25 | Mario Perucho | 1.804 | 2046 | |
| 26 | Ramón Méndez | 1.805 | 2057 | |
| 27 | Bob Villarreal# | 1.814 | 2072 | |
| 28 | Danny Perkins | 1.815 | 2066 | |
| 29 | Mike Bradley | 1.823 | 2022 | |
| 30 | Mathieu Gonthier | 1.856 | 2053 | |
| 31 | Benedict Hess | 1.857 | 1991 | |
| 32 | Tony Casillas | 1.870 | 2019 | |
| 33 | Richard Brown | 1.881 | 2057 | |
| 34 | Jerry Moss | 1.885 | 2065 | |
| 35 | Alan Pak | 1.887 | 2049 | |
| 36 | Marco Montano# | 1.889 | 2074 | |
| 37 | Joe Wallace | 1.890 | 1992 | |
| 38 | Brandon Titley | 1.892 | 2055 | |
| 39 | Will Thomas | 1.893 | 2012 | |
| 40 | Dong-u Jee# | 1.909 | 2073 | |
| 41 | David Barnett | 1.922 | 2013 | |
| 42 | David Santana | 1.929 | 2057 | |
| 43 | Phil Riley | 1.933 | 2041 | |
| 44 | Brett Sellars | 1.934 | 2050 | |
| 45 | Alex Ewing | 1.936 | 2012 | |
| 46 | Adrian Sims | 1.942 | 2059 | |
| 46 | Travis McCarthy | 1.942 | 2009 | |
| 48 | Héctor Guerra | 1.943 | 2040 | |
| 49 | Carlos Gutierrez# | 1.947 | 2070 | |
| 50 | Juan González | 1.958 | 2022 | |
| 51 | Alex Harris | 1.967 | 2042 | |
| 52 | Kichizo Masuda | 1.981 | 2067 | |
| 53 | Luis Sánchez | 1.982 | 2007 | |
| 54 | Qi-zhen Law | 1.986 | 2070 | |
| 55 | Leland Young | 1.987 | 2010 | |
| 56 | Miguel Delgado | 1.990 | 2056 | |
| 57 | Luis Delgado | 1.992 | 2026 | |
| 58 | Ryan Wiley | 1.997 | 1992 | |
| 59 | Dennis Jackson | 1.998 | 1995 | |
| 60 | Johnny Bardwell | 2.004 | 2011 | |
| 61 | Dirkjan Bertels | 2.018 | 2045 | |
| 62 | Júlio Romo | 2.019 | 2023 | |
| 63 | Tristan Phillips | 2.021 | 1993 | |
| 64 | Jin-ho Kwon | 2.027 | 1998 | |
| 65 | Miguel Martínez | 2.033 | 2021 | |
| 66 | Mario Alaniz | 2.043 | 2011 | |
| 67 | Edgar Joyce | 2.051 | 2012 | |
| 68 | Juan López | 2.055 | 2038 | |
| 69 | Ken Thompson | 2.057 | 2010 | |
| 69 | Bob Bright | 2.057 | 2034 | |
| 71 | Javier Herrera | 2.060 | 2002 | |
| 72 | Raúl Rivera | 2.062 | 2054 | |
| 73 | Brit González | 2.077 | 2054 | |
| 74 | Jeremy Thompson | 2.083 | 2011 | |
| 75 | Tony Gómez | 2.086 | 2018 | |
| 76 | Dunieski Vazquez# | 2.087 | 2067 | |
| 77 | John Andrasko | 2.091 | 2063 | |
| 78 | Louwe Terol | 2.092 | 2058 | |
| 78 | Derald Carter | 2.092 | 2046 | |
| 80 | Alberto Coronado | 2.093 | 2012 | |
| 81 | Sergio Coronado | 2.097 | 2008 | |
| 82 | Bob Landry | 2.101 | 2001 | |
| 83 | Manuel Vargas | 2.102 | 2051 | |
| 84 | Jim Thomas | 2.103 | 2008 | |
| 85 | Selme Fraga | 2.106 | 2060 | |
| 86 | Jason Tiley | 2.108 | 2054 | |
| 87 | Jeremiah Williams | 2.111 | 2012 | |
| 88 | Bob Maxwell | 2.116 | 1995 | |
| 89 | Jesse Davis | 2.125 | 2010 | |
| 90 | Eugene Coleman | 2.130 | 2014 | |
| 91 | Bobby Messer# | 2.137 | 2071 | |
| 92 | Jorge Vidales# | 2.143 | 2074 | |
| 93 | Rhett Towers | 2.144 | 2045 | |
| 94 | Lorenzo Macareno | 2.158 | 2058 | |
| 95 | Mike Cunningham | 2.160 | 2037 | |
| 95 | Mark Dand# | 2.160 | 2068 | |
| 97 | Josh Sparks# | 2.166 | 2069 | |
| 98 | Adrian Jimenez | 2.171 | 2071 | |
| 99 | Sebastien Solazzi | 2.172 | 2020 | |
| 99 | Sergio Heredia | 2.172 | 2052 |
